Research progress in the clearance mechanism of platelets stored at 4℃
10.13303/j.cjbt.issn.1004-549x.2022.05.028
- VernacularTitle:4℃冷藏贮存血小板体内清除机制研究进展
- Author:
Bo WANG
1
;
Xian SU
1
;
Shaoduo YAN
1
Author Information
1. Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
- Publication Type:Journal Article
- Keywords:
platelets storage;
storage at 4℃;
platelets storage lesion;
platelet clearance mechanism;
blood transfusion safety
- From:
Chinese Journal of Blood Transfusion
2022;35(5):586-591
- CountryChina
- Language:Chinese
-
Abstract:
Platelets transfusion is one of the most important methods to prevent and treat hemorrhagic diseases.At present, the vitro storage of platelets with gentle agitation at (22±2)℃ is short and susceptible to bacterial contamination, which greatly affects the availability and safety of clinical platelets transfusion.Studies at home and abroad have shown that storage at 4°C could prolong the preservation period of platelets.However, refrigeration may aggravate platelets storage lesion (PSL) and accelerate the clearance mechanism after transfusion, which seriously restricts the clinical application of refrigerated platelets.This paper reviews the research advances in PSL caused by 4℃ storage and the clearance mechanism after transfusion.
