Health economics evaluation of the cost and effectiveness of gray zone setting in blood ELISA screening
10.13303/j.cjbt.issn.1004-549x.2022.07.022
- VernacularTitle:血液筛查ELISA灰区设定的血站支出成本与效果的卫生经济学评估
- Author:
Liqin HUANG
1
;
Le CHANG
2
;
Linfeng WU
1
;
Tong LI
1
;
Ran LI
1
;
Lunan WANG
2
;
Jinfeng ZENG
1
Author Information
1. Shenzhen Blood Centre, Shenzhen 518025, China
2. National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
- Publication Type:Journal Article
- Keywords:
blood screening;
ELISA;
gray zone;
cost-effectiveness analysis
- From:
Chinese Journal of Blood Transfusion
2022;35(7):764-768
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the cost-effectiveness of ELISA grey area strategy through establishing the health economics model. 【Methods】 The serological grey area strategy evaluation model was composed of screening strategy subdecision tree, pathogen infection subdecision tree and pathogen detection subdecision tree. The key parameters in the model were obtained from literatures and research data. The cost-effectiveness of setting ELISA grey area strategy was compared by software, and multifactor sensitivity analysis was conducted. 【Results】 After setting the ELISA grey area, extra samples(5.86 cases/100 000) with serological false negativity could be detected, including HBV samples at 4.93/100 000, HCV samples at 0.27/100 000, HIV samples at 0/100 000, syphilis samples at 0.66/100 000. To yield an additional seropositive sample out of every 100 000 blood donors, blood center will afford extra 1 million yuan about. 【Conclusion】 Through this study, a cost-effectiveness evaluation model of serological detection strategy was established. Although the ELISA grey area setting can yield a small number of seropositive samples, the cost is much higher than the current affordability.
