Effects of micro-Opioid Receptor Gene Polymorphism on Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia with Remifentanil: Double Blinded Randomized Trial.
10.3346/jkms.2015.30.5.651
- Author:
Seung Hyun LEE
1
;
Joo Dong KIM
;
Sol Ah PARK
;
Chung Sik OH
;
Seong Hyop KIM
Author Information
1. Department of Microbiology, Konkuk University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Clinical Trial ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Postoperative Nausea and Vomiting;
Anesthetics, General;
Receptors, Opioid, micro;
Polymorphism, Single Nucleotide
- MeSH:
Adult;
Analgesics, Opioid/*adverse effects;
Anesthesia, General/*adverse effects;
Breast Diseases/surgery;
Demography;
Double-Blind Method;
Female;
Humans;
Methyl Ethers/adverse effects/therapeutic use;
Pain, Postoperative/drug therapy;
Piperidines/*adverse effects/therapeutic use;
*Polymorphism, Single Nucleotide;
Postoperative Nausea and Vomiting/*etiology;
Receptors, Opioid, mu/*genetics
- From:Journal of Korean Medical Science
2015;30(5):651-657
- CountryRepublic of Korea
- Language:English
-
Abstract:
Association between postoperative nausea and vomiting (PONV) and micro-opioid receptor A118G single nucleotide polymorphism (SNP) is undefined and might underlie inconsistent results of studies on PONV occurrence in patients undergoing general anesthesia with the opioid, remifentanil. Four hundred and sixteen Korean women undergoing breast surgery with general anesthesia were randomized to receive remifentanil 10 ng/mL (plasma-site, Minto model) using a target-controlled infusion device and either propofol for total intravenous anesthesia (T group) or sevoflurane for inhalation anesthesia (I group) with bispectral index values maintained between 40 and 60. Blood specimens were collected after anesthesia induction for A118G SNP analysis. PONV and postoperative pain were evaluated. A118G SNP type distribution among Korean female adults studied was AG (n=195)>AA (n=158)>GG (n=63). Regardless of anesthetic technique, patients with GG types had lower PONV scale on arrival at postoperative care unit (PACU) (P=0.002), while T group showed lower PONV scale than I group up to 6 hr after PACU discharge in AA and AG types. No differences were apparent for postoperative pain among opioid receptor polymorphism. PONV occurrence differs according to opioid receptor polymorphism and anesthetic technique in patients undergoing general anesthesia with remifentanil.
