Hepatitis E virus prevalence among blood donors in Wuhan
10.13303/j.cjbt.issn.1004-549x.2022.08.017
- VernacularTitle:武汉地区无偿献血者戊型肝炎病毒感染状况分析
- Author:
Qin YU
1
;
Lei ZHAO
1
;
Tingting XU
1
;
Lijie ZHANG
1
;
Qianhua WANG
2
Author Information
1. Wuhan Blood Center, Wuhan 430000, China
2. Union Hospital, Huazhong University of Science and Technology
- Publication Type:Journal Article
- Keywords:
HEV;
prevalence;
blood donor
- From:
Chinese Journal of Blood Transfusion
2022;35(8):848-851
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the prevalence and risk factor of hepatitis E virus(HEV) infection among blood donors in Wuhan. 【Methods】 A total of 1 302 serum samples (including 1 076 with normal ALT and 226 with elevated ALT) from blood donors were randomly collected from January to December 2021 in Wuhan Blood Center. Anti-HEV IgG, IgM and HEV antigen (Ag) were examined by enzyme-linked immunosorbent assay (ELISA). The IgM or Ag positive and elevated ALT samples were subjected to real time-PCR to detect HEV RNA. Multivariable logistic regression modeling was used to examine the risk factors associated with HEV prevalence. 【Results】 Overall, the positive rates of anti-HEV IgG, IgM, and Ag were 16.44%, 1.0% and 0.08%, respectively. However, none of the serum samples were HEV RNA positive. The prevalence of anti-HEV IgG and anti-HEV IgM was similar in samples with increased ALT and normal ALT (IgG 13.72% vs 17.01%, P>0.05; IgM 1.33% vs 0.93%, P>0.05). Multivariate analysis revealed a strong statistical association between age and HEV IgG seroprevalence. The prevalence increased with increasing age, from 5.4% (18~25 years old) to 68.7%(the highest) in blood donors above 46 years (P<0.05). 【Conclusion】 HEV showed a seroprevalence among blood donors in Wuhan, some of whom were recent infections, suggesting a threat to the safety of blood transfusions. A low anti-HEV prevalence in young adults (18~25 years) is indicative of a susceptible population and implicates a higher risk of HEV infections in this age group in the future.
