Research status and application prospect of hemoglobin-based oxygen carriers in organ transplantation

VernacularTitle:血红蛋白氧载体在器官移植中的研究现状和应用前景
Author: Kewei YOU ^{1
,

2} ; Jiaxin LIU ³ ; Xiangmeng WANG ⁴ ; Wengang WANG ¹
Author Information

1. Redpharm(Beijing) Biopharmaceutical Institute Co., Ltd, Beijing 100176
2. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College
3. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College
4. School of Basic Medical Sciences, Southern Medical University
Publication Type:Journal Article
Keywords: hemoglobin-based oxygen carrier; ischemic reperfusion injury; organ transplantation
From: Chinese Journal of Blood Transfusion 2022;35(8):810-813
CountryChina
Language:Chinese
Abstract: Hemoglobin-based oxygen carriers(HBOCs) is a category of artificial blood substitute with efficient oxygen carrying and delivery functions. Due to the outstanding oxygen-carrying properties of HBOCs, the studies of expanding its clinical applications are undergoing rapidly. Studies have shown the efficacy of HBOCs in organ transplantation as machine perfusion solution in maintaining the organ metabolism or meliorating the margin donor organ quality with promising perspectives. This article aims to review the application status and prospect of HBOCs in organ transplantation in recent years.