Clinical observation of autologous platelet rich plasma in the treatment of diabetes foot ulcer
10.13303/j.cjbt.issn.1004-549x.2022.09.009
- VernacularTitle:自体富血小板血浆治疗糖尿病足溃疡的临床疗效观察
- Author:
Huifen LEI
1
;
Jun XIAO
1
;
Xiaowei LI
1
;
Da ZHANG
2
;
Yiping NING
1
;
Cuiying LI
1
Author Information
1. Blood Transfusion Department, Air Force Characteristic Medical Center, Beijing 100042, China
2. Endocrinology Department, Air Force Characteristic Medical Center, Beijing 100042, China
- Publication Type:Journal Article
- Keywords:
autologous platelet rich plasma;
diabetes foot;
wound healing rate;
ulcer healing
- From:
Chinese Journal of Blood Transfusion
2022;35(9):920-922
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the clinical effect of PRP on refractory ulcer of diabetes foot on the basis of routine treatment. 【Methods】 Sixty-four patients who suffered from diabetes foot and treated in our hospital from January to December 2020 were divided into the routine treatment group (44 cases) vs PRP plus routine treatment group (20 cases, using liquid or gel PRP for diversified treatment) according to a simple random sampling method. The general conditions of the two groups were evaluated to compare the wound surface, wound healing rate, treatment time, wound healing speed rate, adverse reactions and healing conditions after the treatment. 【Results】 The wound surface[0.05(0.00, 0.70)vs 0.35(0.00, 4.54)], wound healing rate[0.99(0.84, 1.00)vs 0.80(0.26, 1.00)] and wound healing speed rate[0.16(0.04, 0.27)vs 0.06(0.01, 0.18)] in PRP group were significantly higher than those in routine treatment group (P<0.05). The treatment duration[18.00(8.75, 24.75)vs 17.00(9.25, 28.00)] between the two groups was not statistically significant (P>0.05), so was the adverse reactions to treatments[0(0/20)vs 2.27(1/44)](P>0.05). The response rate[100(20/20)vs 61.36(27/44)] of PRP group was significantly better than that of routine group, and the difference was statistically significant (P<0.05). 【Conclusion】 The therapeutic effect of PRP group was significantly superior to that of routine treatment group.
