Progress in clinical researches of platelet-rich plasma in the treatment of chronic refractory wounds
10.13303/j.cjbt.issn.1004-549x.2022.10.025
- VernacularTitle:富血小板血浆在慢性难愈性创面治疗中的临床研究进展
- Author:
Wenjuan LI
1
,
2
;
Shuchao ZHANG
2
,
3
Author Information
1. Department of Blood Transfusion, Chengwu County People′s Hospital, Chengwu 274200, China
2. Department of Immunology, College of Basic Medicine, Qingdao University
3. Department of Blood Transfusion, the Affiliated Hospital of Qingdao University
- Publication Type:Journal Article
- Keywords:
platelet-rich plasma;
growth factors;
chronic refractory wounds;
wound healing;
composite materials
- From:
Chinese Journal of Blood Transfusion
2022;35(10):1092-1096
- CountryChina
- Language:Chinese
-
Abstract:
Cutaneous chronic wounds are a major global health burden in continuous growth due to population aging and the higher incidence of chronic diseases, such as diabetes. In the process of spontaneous wound healing, growth factors play a vital role. Thanks to the high content of growth factors in platelet rich plasma(PRP), more and more PRP has been used to treat chronic refractory wounds, including diabetic ulcer, pressure ulcer, venous ulcer, and burns, etc., and has achieved significant results. Given the short duration of local growth factor release in the wound when PRP is applied alone, some studies have combined PRP with different tissue biology materials, such as hyaluronic acid, chitosan, and chitosan derivatives, to achieve better therapeutic results. In this paper, the preparation method of PRP, the mechanism of growth factors, the effect of PRP on wound repair, the combined application of PRP with repair materials and the advantages and disadvantages of PRP are reviewed.
