Investigation on the incidence and risk factors of fetomaternal hemorrhage syndrome in pregnant women in Changsha
10.13303/j.cjbt.issn.1004-549x.2022.10.009
- VernacularTitle:长沙地区孕妇胎母输血综合征发生率及危险因素分析
- Author:
Kexin FAN
1
;
Penghui ZHU
2
;
Yun WANG
2
;
Yongjun WANG
2
;
Ningjie ZHANG
2
Author Information
1. Department of Blood Transfusion, the Second Xianga Hospital of Central South University. Changsha 410011, China
2. Department of Laboratory Medicine, the Second Xianga Hospital of Central South University. Changsha 410011, China
- Publication Type:Journal Article
- Keywords:
fetomaternal hemorrhage syndrome;
pregnant woman;
fetal blood loss;
KB test;
twin pregnancy;
pre-eclampsia;
gestational physiology;
obstetric pathologies;
risk factors
- From:
Chinese Journal of Blood Transfusion
2022;35(10):1031-1034
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the incidence and possible risk factors of FMH among pregnant women in Changsha. 【Methods】 A total of pregnant women (6~42 weeks of gestation) who underwent prenatal examinations in our hospital from June 2019 to December 2020 were enrolled as subjects. In this study, the modified Kleihauer-Betke (K-B) test was used for preliminary screening and flow cytometry was applied to confirme initially positive samples to evaluate the incidence of FMH and estimate fetal blood loss. The logistic regression analysis was used to study the risk factors of FMH. 【Results】 The incidence of FMH in pregnant women was 10.45% (183/1 752), the average volume of fetal blood loss was (2.50±3.87)mL, and 0.11% (2/1 752) of the fetal losed blood > 30 mL. Univariate analysis showed that age, twin pregnancy, pregnancy complicated with uterine fibroids, in vitro fertilization, fetal growth restriction, preeclampsia, and number of pregnancies may be risk factors for FMH. Multivariate analysis showed that twin pregnancy (OR 2.274, 95%CI: 1.135-4.458, P<0.05) and preeclampsia (OR 2.341, 95%CI: 1.082-4.837, P<0.05) were independent risk factors for FMH. 【Conclusion】 Maternal age and various physiological and pathological factors during pregnancy may be associated with the risk of FMH, especially twin pregnancy and pre-eclampsia are independent risk factors for FMH.
