Proteomic characterization of platelet-derived extracellular vesicles induced by different activation pathways
10.13303/j.cjbt.issn.1004-549x.2022.12.020
- VernacularTitle:不同激活条件下血小板来源的细胞外囊泡的蛋白组学研究进展
- Author:
Yang GAO
1
;
Caoyi LIU
2
;
Yu LIU
1
Author Information
1. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu 610052, China
2. Transfusion Department, Chengdu Second People′s Hospital
- Publication Type:Journal Article
- Keywords:
extracellular vesicles;
platelets;
proteomics;
exosomes;
microparticles
- From:
Chinese Journal of Blood Transfusion
2022;35(12):1269-1274
- CountryChina
- Language:Chinese
-
Abstract:
Activated platelets secrete bioactive molecules and extracellular vesicles. Platelet-derived extracellular vesicles(PEVs), which are rich in proteins, have become important mediators of intercellular communication and cargo exchange, being involved in not only hemostasis and thrombosis, but also in immunity and tissue repair. In past decades, many advances have been made in the isolation, characterization and application of PEVs. Platelet activation modes influence the proteomic features of formed extracellular vesicles. The activation ways may be closely related to functional differences. This review summarized the proteomics and functions of PEVs induced by different platelet activation pathways.
