Effect and safety of platelet-rich plasma injection combined with pregabalin in the treatment of knee osteoarthritis
10.13303/j.cjbt.issn.1004-549x.2022.12.012
- VernacularTitle:富血小板血浆注射联合普瑞巴林治疗膝关节骨性关节炎的疗效和安全性评价
- Author:
Juan CHEN
1
;
Hongbing LI
1
;
Zhou CHEN
1
Author Information
1. Department of Blood Transfusion, Qianjiang Central Hospital, Chongqing 409000, China
- Publication Type:Journal Article
- Keywords:
knee osteoarthritis;
pregabalin;
platelet-rich plasma;
pain;
knee function
- From:
Chinese Journal of Blood Transfusion
2022;35(12):1239-1243
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the effects of platelet-rich plasma (PRP) injection combined with pregabalin on pain and knee function in knee osteoarthritis (KOA). 【Methods】 A total of 220 patients with KOA in our hospital, between June 2020 and April 2022, were enrolled and randomly divided into observation group (n=110) and the control (n=110). The observation group was given PRP injection combined with pregabalin, while control group was given sodium hyaluronate combined with pregabalin. The clinical curative effect, osteoarthritis index (WOMAC), pain level (VAS), knee function [Lysholm-Ⅱ scale, Rasmussen scale], levels of repair-promoting factors [transforming growth factor-β1 (TGF-β1), bone morphogenetic protein 4 (BMP4), insulin growth factor 1 (IGF-1)], inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor α (TNF-α)], oxidative stress indexes [superoxide dismutase (SOD), nitric oxide (NO)] and blood routine [white blood cell count (WBC), platelet count (Plt)], and the occurrence of adverse reactions in the two groups were compared. 【Results】 The response rate of treatment was higher in observation group than control group [94.55% (104/110) vs 83.64% (92/110), P<0.05]. After treatment, scores of WOMAC and VAS were lower in observation group than the control group [points: 43.39±5.92 vs 49.40±6.18, 2.50±0.33 vs 2.87±0.39, P<0.05], and scores of Rasmussen and Lysholm-Ⅱ were higher in observation group [points 60.66±6.15 vs 55.13±5.49, 77.04±6.18 vs 72.15±7.25, P<0.05]. After treatment, levels of serum TGF-β1, BMP4 and IGF-1 were higher in observation group than control group [(944.80±54.92) ng/L vs (901.45±46.82) ng/L, (126.79±9.81) pg/mL vs (118.44±8.45) pg/mL, (96.86±5.15) μg/L vs (91.47±5.06) μg/L, P<0.05]. After treatment, levels of serum IL-6, TNF-α and NO were lower in observation group than control group [(124.92±20.58) pg/mL vs (149.10±22.91) pg/mL, (1.90±0.31) μg/L vs (2.64±0.52) μg/L, (81.05±6.83) μmol/L vs (86.22±5.84) μmol/L], while SOD was higher in observation group [(109.29±10.18) NU/mL vs (102.77±9.98) NU/mL, P<0.05)]. The levels of peripheral blood WBC and PLT in the two groups were similar after treatment (P>0.05). There was no significant difference in incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 PRP injection combined with pregabalin can effectively improve knee function, relieve pain, reduce levels of inflammatory factors and oxidative stress injury, and promote the expressions of repair-promoting factors in KOA patients.
