Transfusion of a universal platelet product in hematologic patients for emergency
10.13303/j.cjbt.issn.1004-549x.2022.11.010
- VernacularTitle:一种通用型组合血小板在血液病患者紧急输血中的应用与思考
- Author:
Li ZHANG
1
;
Tao PENG
1
;
Xinyu GAN
1
;
Hua HE
1
;
Jingjing LI
1
;
Liping LIU
1
;
Yicen PU
1
;
Yu QI
1
;
Yajuan WU
1
Author Information
1. Department of Blood Transfusion Medicine, the General Hospital of Western Theater Command, Chengdu 610083, China
- Publication Type:Journal Article
- Keywords:
compatible transfusion;
universal platelets;
emergency blood transfusion
- From:
Chinese Journal of Blood Transfusion
2022;35(11):1131-1135
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the clinical application of a universal platelet product for emergency, which was prepared by suspending O-type apheresis platelet concentrate in AB-type fresh frozen plasma, so as to improve the platelet support ability in emergency and special treatment. 【Methods】 A retrospective analysis of 21 hematological patients, which was divided into 3 groups of platelet transfusion schemes: universal type, AB type and the same type, was performed to analyze the differences in PLT, dose, 24 h PPR, 24 h CCI, follow-up platelet transfusion units and interval, and adverse reactions to transfusion. 【Results】 1)There was no significant difference in PLT, MPV, PDW, K, MA and pH between the initial O-type apheresis platelets and the finished universal platelets (P>0.05). The titers of both anti-A and anti-B in the universal platelets were less than 2. 2) Twenty-one patients were transfused with universal platelet for 27 occasions[1~5 occasions per person; 1 (0.4, 1.0) dose per time]. No adverse reactions to transfusion occurred. 3)There was no significant difference in the effective rate of 24 h CCI and 24 h PPR between the three groups after transfusion(P>0.05). The time interval of the first subsequent platelet transfusion between the compatible group and the universal group was longer than that in the AB-type transfusion group, with significant difference(P<0.05); there was no difference in transfusion dose(P>0.05) among three groups. 【Conclusion】 In emergency, the application of this universal platelet product can make hematological patients get timely and effective treatment. Its accessibility and effectiveness can be elevated and the infusion interval can be prolonged by improving the preparation method and storage conditions. This product is not only expected to improve the platelet support capacity for patients with emergency and also those undergoing hematopoietic stem cell transplantation during the blood type conversion period, but also may be a practical method to alleviate the contradiction between platelet supply and demand.
