Establishment and clinical application of Kidd, Diego, Duffy blood group system, Shaanxi Province
10.13303/j.cjbt.issn.1004-549x.2022.11.008
- VernacularTitle:陕西省Kidd、Diego、Duffy血型数据库的建立及临床应用研究
- Author:
Xiaoyue CHU
1
;
Yong ZHANG
1
;
Juan MAO
1
;
Liangzi ZHANG
1
;
Qinqin ZUO
1
;
Weiwei ZHANG
1
;
Dazhou WU
1
;
Hong WANG
1
;
Hua XU
1
Author Information
1. Shaanxi Blood Center, Xi′an 710061, China
- Publication Type:Journal Article
- Keywords:
rare blood type;
database;
erythrocyte cryopreservation;
clinical application study
- From:
Chinese Journal of Blood Transfusion
2022;35(11):1124-1127
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To screen individuals with rare blood type of Kidd, Diego, Duffy blood group system among the voluntary blood donor in Shaanxi province and to establish on-line and physical database of rare blood type. 【Methods】 Jk(a-b-)phenotype donors were screened by 2 mol/L urea hemolysis test. Blood donors with Di(a+ b-) phenotype were screened by genotyping; Fy(a-) and D-- phenotype donors were screened by modified antiglobulin assay. 【Results】 Three cases of Jk(a-b-) phenotype were detected out of 158 484 voluntary blood donors. The distribution frequency of Jk(a-b-) phenotype was 0.019‰. Di(a+ b-) phenotype was detected in 2(0.436‰) cases out of 4 586 voluntary blood donor. Fy(a-) phenotype was detected in 8(4.034‰) cases out of 1 983 voluntary blood donors. D-- phenotype was not detected in 29 430 voluntary blood donors. 【Conclusion】 The on-line database of Kidd, Diego, Duffy blood group system had been established by large-size screening of blood donor samples, which can conclude the region′s population distribution and genetic characteristics of RBC blood group. And physical database could further be established using the technology of red blood cells cryopreservation when the conditionspermit, so as to provide the most compatible blood for the clinical effectively improve blood transfusion safety, and provide data support for blood early warning.
