Blood coagulation function before and after peripheral blood stem cell mobilization and collection
10.13303/j.cjbt.issn.1004-549x.2022.01.009
- VernacularTitle:外周血造血干细胞动员采集对供者凝血功能影响的研究
- Author:
Dan TIAN
1
;
Gang WANG
1
;
Suying HE
1
;
Shaowen LI
1
;
Chuxia GUO
1
;
Yongzheng PENG
1
;
Zhigang LU
1
Author Information
1. Department of Blood Transfusion, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China
- Publication Type:Journal Article
- Keywords:
PBSC donors;
mobilization/collection of PBSC;
coagulation function;
blood routine
- From:
Chinese Journal of Blood Transfusion
2022;35(1):32-34
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To study the changes of blood coagulation function of donors before and after peripheral blood stem cell(PBSC)mobilization and collection, so as to evaluate the safety of the current scheme. 【Methods】 30 donors who received PBSC mobilization and collection in Zhujiang Hospital from October 2018 to October 2020 were enrolled. After mobilization by G-CSF, the correlation between coagulation function, blood routine indexes and TEG indexes of donors was analyzed, and the influence of PBSC mobilization and collection on coagulation function of donors was evaluated. 【Results】 The TEG indexes R(min), K(min), α(°), MA(mm) and CI before and after PBSC collection were 6.12±1.18 vs 7.25±2.16, 1.98±0.41 vs 2.45±0.64, 62.82±4.98 vs 57.3±6.67, 60.93±3.26 vs 55.37±4.41, and -0.31±1.40 vs -2.32±2.18, respectively(P<0.05), suggesting that there was no risk of hypercoagulability after PBSC mobilization and collection. The peak values of WBC (×109/L), Plt (×109/L) and Hb (g/L) were 62.02, 357 and 162, respectively, which indicated that the blood routine indexes after PBSC mobilization and collection were in the safe range. After PBSC collection, the CI value of 26.7% (8/30) donors was less than -3, showing hypocoagulability. 【Conclusion】 The current mobilization and collection scheme of PBSC has little effect on the coagulation function. Most of the donors had no risk of hypercoagulability, but a few showed a trend of hypocoagulability after PBSC collection.
