HBV infection in window period among repeated blood donors: Residual risk assessment and trend analysis
10.13303/j.cjbt.issn.1004-549x.2021.11.017
- VernacularTitle:重复献血者HBV窗口期残余风险评估及趋势研究
- Author:
Yuning LIU
1
;
Yao JIA
2
;
Haiying WANG
1
;
Juying CAI
1
;
Zhihua SU
1
;
Xun WANG
2
Author Information
1. Fengxian Blood Bank, Shanghai 201400, China
2. Shanghai Blood Center
- Publication Type:Journal Article
- Keywords:
residual risk;
HBV;
repeated blood donation;
windows period;
nucleic acid testing (NAT)
- From:
Chinese Journal of Blood Transfusion
2021;34(11):1231-1234
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the status of blood safety and the effectiveness of preventive measures. 【Methods】 The data of Fengxian Blood Bank from 2018 to 2020 were extracted from Shanghai blood collection and supply information system. HBsAg sero-conversion samples of repeated blood donors were confirmed, and HBV serologic supplemental test were performed to obtain the number of new infections during the blood donation interval. The incidence and residual risk of HBV infection were evaluated by the sero-conversion model in donation intervals for repeated donors, and residual risk trend between the study period of 2002 to 2005, 2007 to 2011, 2011 to 2013 and 2018 to 2020 was compared. 【Results】 During 2018~2020, nine new HBV infections occurred among repeated donors during blood donation interval, with an incidence rate of 2.71 per 10 000. The residual risk of window period HBV transmission by transfusion could be reduced by 58.33% using HBsAg test plus NAT (HBsAg test 1∶30 637 vs HBsAg test plus NAT 1∶73 529). The residual risk of HBV transmission was decreasing when stratifying by periods, especially one order of magnitude dropped in 2018~2020 as in comparison of 2002 to 2005. 【Conclusion】 The residual risk of HBV transmission by transfusion showed a decrease trend. Although NAT could greatly reduce the risk, comprehensive preventive measures are needed to further reduce the risk.
