Prevalence of hepatitis E virus infection among blood donors
10.13303/j.cjbt.issn.1004-549x.2021.11.006
- VernacularTitle:无偿献血者戊型肝炎病毒核酸筛查的研究
- Author:
Xiaomin DU
1
;
Jun CAI
1
;
Chongqian HUA
1
;
Hongjing NIU
1
;
Jiang QIAN
1
Author Information
1. Jinhua Blood Center, Jinhua 321000, China
- Publication Type:Journal Article
- Keywords:
hepatitis E virus;
HEV NAT;
anti-HEV ELISA;
voluntary blood donors;
blood safety;
NAT
- From:
Chinese Journal of Blood Transfusion
2021;34(11):1197-1199
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the prevalence of hepatitis E virus (HEV) among voluntary blood donors, and the viability and practicability of nucleic acid testing (NAT) in Jinhua area. 【Methods】 Blood samples from 1 017 voluntary blood donors at Jinhua Blood Center from April to May 2021 were collected, and HEV RNA was detected by CHURAS BSS1200 blood nucleic acid detection system. The reactive samples were re-tested for IgM and IgG antibodies by ELISA, and HEV genotyping by gene sequencing. 【Results】 The yield rate of HEV RNA out of voluntary blood donors in Jinhua was 0.98 ‰ (1 / 017). The individual was negative for IgM and IgG antibodies, but was confirmed to be HEV RNA genotype 4 by sequencing. 【Conclusion】 HEV RNA positive donors have been found in this study. HEV RNA blood screening can effectively enhance the safety of blood transfusion.
