Effect of platelet donation frequency on iron, cooper, and zinc content and superoxide dismutase activity
10.13303/j.cjbt.issn.1004-549x.2021.12.030
- VernacularTitle:血小板捐献次数对血浆铁铜锌含量及SOD活性影响的初步研究
- Author:
Li NING
1
;
Yanyan ZHANG
1
;
Zetao SUN
1
;
Yuchuan WANG
2
;
Xiubo DU
3
;
Jiangyun WANG
2
;
Liang LU
1
;
Yunping XU
1
Author Information
1. Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen 518035, China
2. Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
3. College of Life Sciences and Oceanography, Shenzhen University
- Publication Type:Journal Article
- Keywords:
apheresis platelets;
microelement;
superoxide dismutase
- From:
Chinese Journal of Blood Transfusion
2021;34(12):1388-1391
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To study the effects of platelets donation frequency on iron, copper, zinc content and superoxide dismutase(SOD) activity in plasma of blood donors. 【Methods】 128 apheresis platelet donors from August 25, 2020 to August 25, 2021 in our center were divided into 4 groups according to the frequency of platelet donation: first-time donors(n=30) were enrolled as group 1, and donors with 2 to 7 donations(n=23), 8 to 14 donations(n=29), 15 to 24 donations(n=46) within the previous period were group 2, group 3 and group 4. All these donors were males, with the average age of 42 ± 8.3, and had not donated whole blood in the past two years. Inductively coupled plasma mass spectrometry(ICP-MS) was used to detect the content of copper, iron and zinc in plasma of different groups of platelet donors. The SOD activity was detected by WST colorimetric kit. All data were statistically analyzed by SPSS 19.0 software. 【Results】 Significant differences in the content of iron and copper, but no in zinc, were noticed in donors of different groups(P<0.05). Multiple comparison showed that first-time blood donors presented significantly higher iron content but significantly lower copper content than those of donors with 15 to 24 blood donations per year(P<0.05), and no significant difference was found in iron and copper content among other groups(P>0.05). There was no significant difference in zinc content between every two groups(P>0.05). The SOD inhibition rate of blood donors in different groups was not significantly different. 【Conclusion】 The content of plasma iron, copper, and zinc and the SOD activity were not significantly affected if platelet donations were less than 15 times within a year. For those donated platelets more than 15 times within a year, the content of iron was found to decrease and copper to increase. It is suggested that platelet donations more than 15 times is correlated with the content of iron and copper in plasma of blood donors. Therefore, the proportion of iron-rich food should be appropriately increased in the daily diet for high-frequency(≥15 times per year) apheresis platelet donors after blood donation.
