Study on gene polymorphism of multiple RBC blood group systems in Mongolian population in Inner Mongolia

Rongpeng WANG; Yangyang ZHENG; Feng CHEN

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Study on gene polymorphism of multiple RBC blood group systems in Mongolian population in Inner Mongolia

VernacularTitle:内蒙古地区蒙古族人群多种红细胞血型系统基因的多态性研究
Author: Rongpeng WANG ^{1
,

2} ; Yangyang ZHENG ¹ ; Feng CHEN ¹
Author Information

1. Inner Mongolia People’s Hospital. Hohhot 010020, China
2. Inner Mongolia Medical University
Publication Type:Journal Article
Keywords: rare blood type; gene polymorphism; gene frequency; precision transfusion; Mongolian
From: Chinese Journal of Blood Transfusion 2021;34(12):1305-1309
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the gene frequency and polymorphism of 12 RBC blood group systems, including RHCE, Lw, Duffy, Kidd, MNS, Scianna, Colton, Dombrock, Kell, Diego, Yt, and Lutheran blood group systems in Mongolian in Inner Mongolia, so as to provide data for the establishment of rare blood group registry in this region. 【Methods】 Twelve blood groups of 220 Mongolian people in Inner Mongolia were genotyped and analyzed by Fluo-PCR. 【Results】 The genes frequency of the 12 rare blood group was as follows: 1)RhCE, C=0.613 6, c=0.386 4, E=0.265 9, e=0.734 1; MNS, M=0.609 1, N=0.390 9, S=0.063 6, s=0.931 8, Mur=0; Duffy, Fy^a=0.856 8, Fy^b=0.143 2; Kidd, Jk^a=0.522 7, Jk^b=0.477 3; Diego, Di^a=0.027 3, Di^b=0.972 7, Wr^a=0, Wr^b=1; Dombrock, Do^a=0.163 6, Do^b=0.836 4. 2) Kell, K=0.002 3, k=0.997 7, Kp^a=0.009 1, Kp^b=0.990 9; Yt, Yt^a=0.986 4, Yt^b=0.013 6. 3) Lw, Lw^a=1, Lw^b=0; Sc2=0; Colton, Co^a=1, Co^b=0; Lutheran, Lu^a=0, Lu^b=1. The 220 Mongolian people with Lw, Scianna, Colton and Lutheran were all homozygous, and their genotypes were Lw^a/Lw^a, Sc1/Sc1, Lu^b/Lu^b and Co^a/Co^a, respectively. 【Conclusion】 The RHCE, MNS, Duffy, Kidd, Diego and Dombrock blood types of Mongolian population in Inner Mongolia are polymorphic with certain distribution characteristics. The MNS blood group system does not conform to the Hardy-Weinberg equilibrium(P<0.05), which may be related to the sample size or genetic changes. Kell, Lw, Scianna, Colton, Yt and Lutheran showed a monomorphic distribution.