Blood matching incompatibility caused by cold autoantibodies and IgG anti S antibody: a case report
10.13303/j.cjbt.issn.1004-549x.2023.12.021
- VernacularTitle:冷自身抗体伴IgG抗-S致配血不合1例
- Author:
Chen MA
1
Author Information
1. Zibo Central Blood Station, Zibo 255000, China
- Publication Type:Journal Article
- Keywords:
cold autoantibodies;
anti S antibody;
cross matching;
transfusion safety
- From:
Chinese Journal of Blood Transfusion
2023;36(12):1165-1167
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the serological characteristics of an anemia patient with cold autoantibodies and IgG anti S antibody. 【Methods】 Unexpected antibody screening was performed on screening cells, autologous cells and panel cells with patient serum in saline and anti human globulin card media at room temperature and 37 ℃, respectively. At the same time, the serum that destroying IgM antibodies and acid elution solution were respectively screened for unexpected antibodies in anti human globulin card media. The absorption-elution test was used to treat patients′ red blood cells and serum, and the unexpected antibody identification and cross matching were performed after excluding the interference of cold autoantibodies. 【Results】 Cold autoantibodies and IgG anti S antibody were found in the serum of this patient. 【Conclusion】 When a patient is found to have cold autoantibodies, it is necessary to screen the alloantibody, in order to avoid post transfusion immune reactions due to missed detection of alloantibody.
