Predictive value of preoperative liver function for perioperative massive blood transfusion in patients undergoing ascending aorta surgery
10.13303/j.cjbt.issn.1004-549x.2023.12.009
- VernacularTitle:术前肝功能对升主动脉手术患者围术期大量输血的预测价值
- Author:
Lihui QIAN
1
;
Caimin ZHU
1
;
Zhangsheng ZHAO
1
;
Lei WANG
1
;
Wei ZHOU
1
;
Qile XIN
1
;
Youli MA
1
;
Qitian MU
2
Author Information
1. The Affiliated Lihuili Hospital of Ningbo University, Ningbo 315040, China
2. The First Affiliated Hospital of Ningbo University
- Publication Type:Journal Article
- Keywords:
liver function;
aspartate aminotransferase;
ascending aortic surgery;
type A aortic dissection;
massive blood transfusion
- From:
Chinese Journal of Blood Transfusion
2023;36(12):1118-1123
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the predictive value of preoperative liver function for massive blood transfusion (MBT) in patients undergoing ascending aorta surgery. 【Methods】 Data from 238 patients undergoing ascending aorta surgery in the Department of Cardiovascular Surgery at The Affiliated Lihuili Hospital of Ningbo University were collected. Preoperative liver function tests were performed for all patients. Based on the perioperative transfusion volumes of red blood cell suspension, patients were divided into the MBT group, non-MBT group, and no blood transfusion (NBT) group. Clinical data during the perioperative period were compared among different groups. Receiver operating characteristic curve (ROC curve) analysis was used to assess the predictive value of liver function indicators for MBT and determine cut-off values. 【Results】 Compared with the non-MBT group and NBT group, the MBT group showed statistically significant differences in preoperative levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), direct bilirubin (DBIL), and serum albumin (SA) (P<0.05). ROC curve analysis revealed that AST had the largest area under the curve (AUC) for predicting MBT, with a value of 0.723. ALT had the highest specificity for predicting MBT at 86.7%, and SA had the highest sensitivity at 89.7%. When AST >28.50 U/L, ALT >40.00 U/L, SA ≤34.55 g/L, and DBIL >4.25 μmol/L, there was a significant increase in the transfusion volume of various blood components and the incidence of MBT. 【Conclusion】 Preoperative liver function indicators (AST, ALT, SA, DBIL) have a moderate predictive value for MBT in patients undergoing ascending aorta surgery.
