Detection and analysis of antibodies against SARS-CoV-2 in blood donors at different periods in Guangzhou
10.13303/j.cjbt.issn.1004-549x.2023.12.003
- VernacularTitle:广州地区无偿献血人群不同时期新冠病毒抗体检测分析
- Author:
Zhengang SHAN
1
;
Hualong YANG
2
;
Ledong YANG
1
;
Jieting HUANG
1
;
Min WANG
1
;
Ru XU
1
;
Qiao LIAO
1
;
Huishan ZHONG
1
;
Bochao LIU
1
;
Yongshui FU
1
,
3
;
Xia RONG
1
Author Information
1. Institute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou 510095, China
2. School of Laboratory Medicine and Biotechnology, Southern Medical University
3. School of Laboratory Medicine and Biotechnology, Southern Medical University
- Publication Type:Journal Article
- Keywords:
blood donor;
SARS-CoV-2;
antibody
- From:
Chinese Journal of Blood Transfusion
2023;36(12):1094-1097
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To detect the anti-SARS-CoV-2 antibody levels in blood donors in Guangzhou, so as to provide laboratory data support for the collection and clinical use of convalescent plasma. 【Methods】 Anti-SARS-CoV-2 antibodies were measured by ELISA in qualified donors. Among them, 326 donors who gave blood in February 2023 were tested for IgG antibodies, 444 donors were tested for neutralizing antibodies. In July 2023, 398 donors were tested for IgG and IgM. 【Results】 399 of 724 blood samples diluted with normal saline (1∶160) were IgG reactive, with a reactive rate of 55.11%. Chi-square test showed that there was a significant difference in the reactive rate of IgG among samples collected at different times (25.46% in February vs 79.40% in July, χ2=210.74, P<0.01, 95%CI: 7.97, 15.98), but there was no significant difference in the reactive rate between different genders and different age groups. IgM was detected in 5 of 398 blood samples, with a reactive rate of 1.26%. The IgG test results of these five blood donors were all reactive, whereas the nucleic acid test results were negative. Neutralizing antibody was detected in 440 of 444 blood samples, with a reactive rate of 99.10%, and 71.59% of the reactive donors had a neutralizing antibody level of 10 μg/mL or more. 【Conclusion】 Blood donors in Guangzhou have a high level of SARS-CoV-2 antibody, which is sufficient to provide convalescent plasma for clinical treatment.
