Antigen profile and antibody frequency of Wr<sup>a</sup> in voluntary blood donors in Shaanxi province, containing 2 clinical cases of anti-Wr<sup>a</sup> identification

VernacularTitle:陕西地区无偿献血者Wr^a抗原分布多态性及其抗体频率调查
Author: Xiaoyue CHU ; Qinqin ZUO ; Juan MAO ; Dazhou WU ; Weiwei ZHANG ; Hong WANG ; Liangzi ZHANG ; Hua XU
Publication Type:Journal Article
Keywords: anti-Wr^a; Wr^a antigen; genotyping; antigen polymorphism
From: Chinese Journal of Blood Transfusion 2021;34(1):52-54
CountryChina
Language:Chinese
Abstract: 【Objective】 To understand the antigen profile and antibody frequency of Wr^a in voluntary blood donors in Shaanxi province. 【Methods】 Wr^a antigen and antibody screening as well as blood group typing and antibody identification were performed by serological tests and confirmed by genetic testing. 【Results】 The incidence of Wr^a antigen in 7 490 voluntary blood donors was 0.013%(1/7 490), and the frequency of anti-Wr^a in 729 voluntary blood donors was 0.823%(6/729). 【Conclusion】 This study explored the polymorphism of Wr^a antigen and antibodies in blood donors, which is informative in the risk assessment of blood transfusion and the screening and identification of respective antibodies.