Superior Cervical Sympathetic Ganglion Block may not Influence Early Brain Damage Induced by Permanent Focal Cerebral Ischemia in Rats.
- Author:
Hyun Hae KIM
1
;
Jeong Gill LEEM
;
Jin Woo SHIN
;
Ji Yeon SHIM
;
Dong Myung LEE
Author Information
- Publication Type:Original Article
- Keywords: cervical sympathetic ganglion block; focal cerebral ischemia; rat
- MeSH: Amides; Animals; Blood Vessels; Brain; Brain Injuries; Brain Ischemia; Edema; Ganglia, Sympathetic; Humans; Infarction; Infarction, Middle Cerebral Artery; Lidocaine; Male; Neuroprotective Agents; Nylons; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion
- From:The Korean Journal of Pain 2008;21(1):33-37
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: Cerebral blood vessels are innervated by sympathetic nerves from the superior cervical ganglion (SCG). The purpose of the present study was to evaluate the neuroprotective effect of superior cervical sympathetic ganglion block in rats subjected to permanent focal cerebral ischemia. METHODS: Thirty male Sprague-Dawley rats (270-320 g) were randomly assigned to one of three groups (control, lidocaine and ropivacaine). A brain injury was induced in all rats by middle cerebral artery occlusion with a nylon thread. The animals of the local anesthetic group received 30 microl of 2% lidocaine or 0.75% ropivacaine in the SCG. Neurologic scores were assessed 24 hours after brain injury. Brain samples were then collected. The infarct and edema ratios were measured by 2.3.5-triphenyltetrazolium chloride staining. RESULTS: There were no differences in the death rates, neurologic scores, or infarction and edema ratios between the three groups. CONCLUSIONS: These findings suggest that superior cervical sympathetic ganglion block may not influence the brain damage induced by permanent focal cerebral ischemia in rats.
