Role of androgen receptors in the development of hepatocellular carcinoma
10.19428/j.cnki.sjpm.2023.22926
- VernacularTitle:雄激素受体在肝细胞癌发生发展中的作用
- Author:
Yitao YANG
1
;
Yu GU
1
;
Ziyan CHEN
1
;
Wenbin LIU
1
;
Guangwen CAO
1
Author Information
1. Department of Epidemiology， Naval Medical University， Shanghai 200433， China
- Publication Type:Review
- Keywords:
hepatocellular carcinoma;
gender difference;
androgen receptor;
molecular mechanism;
hepatitis B virus
- From:
Shanghai Journal of Preventive Medicine
2023;35(11):1157-1161
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma （HCC） has emerged as a significant public health concern， posing a serious threat to the lives and health of residents in China. Furthermore， the incidence and mortality rates of HCC are notably higher in males than in females. Androgen receptors （AR） can contribute to the occurrence of male-specific cancers such as prostate cancer， suggesting a potential link to the increased susceptibility of males to HCC. Elucidating the cancer-promoting mechanism of AR and developing specific targeted interventions are effective ways to advance tertiary prevention of HCC and improve patient prognosis. This paper reviews the relevant evidence of AR’s role in promoting the occurrence and development of HCC， summarizes relevant mechanisms discovered to date， including promoting the stemness of HCC cells， altering the immune microenvironment， regulating key signaling pathways， inducing glycolysis in hepatocellular carcinoma， and synergizing with hepatitis B virus to promote HCC. Additionally， research directions for targeted interventions in HCC through AR-related signaling pathways are discussed.
