Contribution of tobacco smoking to the risk of novel coronavirus infection and related mechanisms
10.19428/j.cnki.sjpm.2023.22942
- VernacularTitle:吸烟对新型冠状病毒感染的促进作用和相关机制
- Author:
Ruixi GUO
1
;
Jintao LING
1
;
Bodong WANG
1
;
Wenbin LIU
2
;
Guangwen CAO
2
Author Information
1. College of Basic Medical Sciences， Naval Medical University， Shanghai 200433， China
2. Department of Epidemiology， Naval Medical University， Shanghai Key Laboratory of Medical Bioprotection， Key Laboratory of Biological Defense， Ministry of Education， Shanghai 200433， China
- Publication Type:Review
- Keywords:
smoking;
SARS-CoV-2;
viral infection;
epidemiology;
molecular mechanism
- From:
Shanghai Journal of Preventive Medicine
2023;35(11):1153-1156
- CountryChina
- Language:Chinese
-
Abstract:
The severe acute respiratory syndrome coronavirus 2 （SARS-CoV-2） and its variants are still globally spreading. Vaccines can reduce the mortality， but cannot eliminate the risk of infection. The identification and protection of the high-risk susceptible population remains of great importance for the prevention and control of SARS-CoV2 and other coronavirus infections. Smoking is an important risk factor for many respiratory diseases， and therefore may also influence the risk of SARS-CoV2 infection and the disease progression after infection. This study reviewed the epidemiological and mechanistic evidence supporting the relationship between tobacco exposure and SARS-CoV2 infection， summarized the contributing effects of tobacco exposure to the infection risk， disease severity， and mortality of COVID-19， and analyzed the molecular mechanisms by which cigarette smoking affects COVID-19 through regulating inflammatory microenvironment and gene expression.
