Current Status and Progress of Diagnostic Techniques for Cancer of Unknown Primary
10.3971/j.issn.1000-8578.2023.23.0770
- VernacularTitle:原发灶不明肿瘤的诊断技术现状及进展
- Author:
Peng QI
1
;
Yifeng SUN
;
Qinghua XU
;
Xiaoyan ZHOU
Author Information
1. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
- Publication Type:Research Article
- Keywords:
Cancer of unknown primary;
Molecular Diagnostics;
Gene Detection;
Targeted Therapy;
Immunotherapy
- From:
Cancer Research on Prevention and Treatment
2023;50(12):1160-1164
- CountryChina
- Language:Chinese
-
Abstract:
Cancer of unknown primary (CUP) is a heterogeneous tumor type that has been diagnosed as a metastatic tumor by pathological examination, but the primary tumor cannot be identified through comprehensive clinical examination. The incidence of CUP accounts for approximately 1%–2% of all tumors. CUP progresses rapidly and has a short course. The treatment and prognosis of patients with CUP are closely linked to the primary site. In clinical settings, identifying the primary tumor remains challenging. Scholars have focused on improving the detection rate. Novel technologies, such as gene expression profiling, high-throughput sequencing, epigenetics, and liquid biopsy, have been successively applied to identify the primary tumor of CUP accurately, sensitively and specifically. With the guidance of molecular diagnosis, targeted therapy, immunotherapy, and combination therapy will usher in the era of precision treatment for CUP, which may become a typical example for individualized therapy.
