Effect of Intestinal Microecology on Diabetic Kidney Disease Based on Yin-Yang Theory
10.13422/j.cnki.syfjx.20230827
- VernacularTitle:基于中医阴阳理论探讨肠道微生态对糖尿病肾脏病的影响
- Author:
Chao MO
1
;
Guodong HUANG
2
;
Wei SHI
3
;
Jie ZHAO
4
Author Information
1. Graduate School， Guangxi University of Chinese Medicine，Nanning 530200，China
2. Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine，Nanning 530219，China
3. The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530000，China
4. Graduate School，Hunan University of Chinese Medicine，Changsha 410208，China
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
intestinal microecology;
Yin-Yang theory;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(3):178-186
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is the main cause of end-stage renal disease. Its high prevalence， mortality rate， and medical cost bring a heavy economic burden to society and families， and DKD has become one of the most important public health problems. Intestinal microecology is the most important and complex micro-ecosystem in the human body， which is involved in important life activities such as material and energy metabolism， immune system regulation， and signal transduction， thereby maintaining the dynamic balance of the human internal environment. The dynamic balance between the intestinal microecology and the body is essentially a Yin-Yang balance. Once this balance is broken， intestinal microbiota imbalance， intestinal mucosal barrier damage， immune dysfunction， and reduction of metabolite short-chain fatty acids （SCFAs） will occur， which play an important role in the progression of DKD. From the perspective of the Yin-Yang theory of traditional Chinese medicine （TCM）， the imbalance of intestinal microecology in DKD is equivalent to the excessive or insufficient constraint of Yin and Yang， or Yin deficiency affecting Yang， or Yang deficiency affecting Yin， or waning and waxing of Yin and Yang. For different pathogenesis changes， "Yin disease treated through Yang"， "treating Yin for Yang"， or "treating Yang for Yin" methods are adopted to regulate intestinal microbiota， inhibit immune inflammation， protect intestinal mucosal barrier， and increase SCFAs through TCM， thereby reconciling Yin and Yang to achieve the condition where "Yin is at peace and Yang is compact". Based on the Yin-Yang theory， this paper intended to interpret the scientific connotation of TCM in the treatment of DKD with intestinal microecology as the target and TCM in the treatment of DKD by regulating intestinal microecology as the breakthrough point to provide a novel insight for the occurrence and development of DKD and the mechanism of TCM.
