Connotation of Traditional Chinese Medicine in Treatment of Chronic Obstructive Pulmonary Disease by Regulating Gut Microbiota Based on "Lung and Large Intestine Being Interior-exterior Related"
10.13422/j.cnki.syfjx.20231417
- VernacularTitle:基于“肺与大肠相表里”探讨中医药调控肠道菌群治疗慢性阻塞性肺疾病的内涵
- Author:
Hanxiao WANG
1
;
Zheyu LUAN
1
;
Jihong FENG
2
Author Information
1. Tianjin University of Traditional Chinese Medicine （TCM）， Tianjin 301617， China
2. The Second Affiliated Hospital of Tianjin University of TCM， Tianjin 300250， China
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
gut microbiota;
traditional Chinese medicine;
lung and large intestine being exterior-interior related
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(3):169-177
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease （COPD） is a heterogeneous lung condition characterized by persistent and often progressive airflow obstruction， including airway abnormalities （e.g.， bronchitis and bronchiolitis） and chronic respiratory symptoms （e.g.， dyspnea， cough， and expectoration）. It is one of the leading causes of death worldwide. According to the theory of traditional Chinese medicine （TCM）， the lung and large intestine are interior-exterior related. Therefore， COPD can be treated from both the lung and intestine by the methods of tonifying and invigorating lung， spleen， and kidney， dispelling phlegm， and expelling stasis. Gut microbiota plays a key role in human immunity， nerve， and metabolism and may act on COPD by affecting the structures and functions of lung and intestine tissue and regulating lung inflammation and immunity. TCM can restore the balance of gut microbiota， which is conducive to the recovery from COPD. For example， the treatment method of tonifying lung and invigorating kidney can regulate gut microbiota， alleviate pulmonary and intestinal injuries， and improve lung immunity. The treatment methods of dispelling phlegm and expelling stasis can regulate gut microbiota and reduce pulmonary inflammation. According to the TCM theory of lung and large intestine being interior-exterior related， this review elaborates on the connotation of TCM in the treatment of COPD by regulating gut microbiota， aiming to provide new ideas for the clinical treatment of COPD via gut microbiota.
