Sex Reversal Syndrome (SRS): A case of SRY-Positive 46,XX Testicular Disorder

Author: Kishore Shil ¹ ; Tahmina Ferdousi ¹ ; Tahniyah Haq ¹ ; MA Hasanat ¹
Author Information

1. Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Publication Type:Case Reports
Keywords: Sex Reversal Syndrome; 46XX with SRY positive; Genetic analysis
From: Journal of the ASEAN Federation of Endocrine Societies 2023;38(2):141-144
CountryPhilippines
Language:English
Abstract: We report a case of an SRY-positive 46,XX Indian male who presented with small testis and phallus, poor beard and mustache development and gynecomastia at the age of 24 years. He was biochemically found to have hypergonadotropic hypogonadism. He had 46,XX karyotype and Quantitative Fluorescence-PCR (QF-PCR) identified the SRY gene on the X chromosome. SRY-positive 46 XX male SRS cases usually present as phenotypically male since birth but develop features of hypogonadism, poor testicular development, and infertility after puberty. Infertility, hypogonadism, external genital development, and psychological distress are the major concerns during the management of the patients. Testosterone therapy for hypogonadism, artificial reproductive technologies for fertility, surgical repair of hypospadias/cryptorchidism/under-virilized genitalia and psychological and genetic counseling are helpful for proper management of the patients.
Full text:2539-Article Text-25131-1-10-20231115.pdf