A cross-sectional study to assess beta-cell function in individuals with recently diagnosed young-onset type 2 diabetes mellitus and its’ complications
https://doi.org/10.15605/jafes.038.02.13
- Author:
Shamharini Nagaratnam
1
;
Subashini Rajoo
2
;
Mohamed Badrulnizam Long Bidin
2
;
Nur Shafini Che Rahim
3
;
Sangeetha Tharmathurai
4
;
Masita Arip
5
;
Yee Ming Ching
5
;
Siew Hui Foo
1
Author Information
1. Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia
2. Endocrine Unit, Department of Medicine, Hospital Kuala Lumpur, Malaysia
3. Department of Pathology, Kuala Lumpur Hospital, Malaysia
4. Department of Ophthalmology, Kuala Lumpur Hospital, Malaysia
5. Allergy and Immunology Centre, Institute for Medical Research (IMR), National Institute of Health, Selangor, Malaysia
- Publication Type:Journal Article
- Keywords:
Young onset;
Beta cell function;
Glucagon stimulation test
- MeSH:
Diabetes Mellitus, Type 2;
C-Peptide
- From:
Journal of the ASEAN Federation of Endocrine Societies
2023;38(2):20-27
- CountryPhilippines
- Language:English
-
Abstract:
Objective:The primary objective was to assess beta-cell function of recently-diagnosed young-onset type 2 diabetes mellitus (T2DM) individuals using basal and stimulated C-peptide levels. The secondary objective was to examine the association between C-peptide with metabolic factors and diabetes complications.
Methodology:A cross-sectional study was conducted for young-onset T2DM individuals aged 18-35 years with a disease duration of not more than 5 years. Plasma C-peptide was measured before and after intravenous glucagon injection. Demographic data, medical history and complications were obtained from medical records and clinical assessment. Continuous data were expressed as median and interquartile range (IQR). Categorical variables were described as frequency or percentage. Multivariable linear regression analysis was used to determine factors associated with C-peptide levels.
Results:113 participants with young-onset T2DM with a median (IQR) age of 29.0 (9.5) years and 24 (36) months were included in this study. The median (IQR) basal and stimulated C-peptide was 619 (655) pmol/L and 1231 (1024) pmol/L. Adequate beta-cell function was present in 78-86% of the participants based on the basal and stimulated C-peptide levels. We found hypertension, obesity and diabetic kidney disease (DKD) to be independently associated with higher C–peptide levels. In contrast, females, smokers, those on insulin therapy and with longer duration of disease had lower C–peptide levels.
Conclusion:Most recently diagnosed young-onset T2DM have adequate beta-cell function. Elevated C-peptide levels associated with obesity, hypertension and diabetic kidney disease suggest insulin resistance as the key driving factor for complications.
- Full text:2563-Article Text-25093-1-10-20231115.pdf
