Effects of ethanol and propylene glycol alone or in combination on the transdermal properties of triamcinolone acetonide spray solution
10.12206/j.issn.2097-2024.202208022
- VernacularTitle:乙醇和丙二醇单用与联用对曲安奈德喷雾溶液透皮性能的影响
- Author:
Qiaoyan MA
1
;
Rong LI
2
;
Fengjiao LI
2
;
Ru SUN
2
;
Xiaohua DAI
1
;
Liwei JI
2
Author Information
1. College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830052，China.
2. Shandong Lukangshelile Pharmaceutical Co., Ltd, Jining 272000，China.
- Keywords:
triamcinolone acetonide spray;
in vitro transdermal test;
franz diffusion cell;
HPLC
- From:
Journal of Pharmaceutical Practice
2023;41(12):733-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct in vitro transdermal test on triamcinolone acetonide spray solution, and investigate the effects of ethanol and propylene glycol alone or in combination on the in vitro transdermal function of triamcinolone acetonide spray solution. Methods Rabbit abdominal skin was selected, and the in vitro penetration test of triamcinolone acetonide spray solution was carried out by Franz diffusion cell method, and the content of triamcinolone acetonide was determined by HPLC. The rate of transdermal absorption was compared. Results The transdermal absorption rate of the combined use of ethanol and propylene glycol was significantly higher than that of the single use (P<0.05), and the order of promoting the penetration of triamcinolone acetonide spray solution when ethanol and propylene glycol were combined by 10% ethanol + 25% propylene glycol >10% ethanol + 20% propylene glycol >15% ethanol + 25% propylene glycol >15% ethanol + 20% propylene glycol. Conclusion The combination of 10% ethanol and 25% propylene glycol could optimize the transdermal function of triamcinolone acetonide spray solution.
