Progress of researches on molecular mechanisms underlying helminth infection-mediated type 1/2 host immune responses.
10.16250/j.32.1374.2023101
- Author:
Q MU
1
;
B ZHOU
1
Author Information
1. Department of Parasitology, Zunyi Medical University, Zunyi, Guizhou 563000, China.
- Publication Type:Journal Article
- Keywords:
Helminth;
Immune response;
Molecular mechanism;
Signaling pathway
- MeSH:
Animals;
Humans;
Helminthiasis;
Helminths;
Immunity, Innate;
Signal Transduction;
Host-Parasite Interactions
- From:
Chinese Journal of Schistosomiasis Control
2023;35(5):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Helminth infections are widespread worldwide, and pose a serious threat to human health and animal husbandry development. Understanding of helminth-host interactions is critical to effective control and ultimate eradication of helminthiasis. Following host infections, helminth infections firstly initiate innate immune responses and then mediate adaptive immune responses. Type 1 immune responses are predominant at early stage of helminth infections, which mainly play anti-infective actions, and type 2 immune responses are predominant at late stage of infections, which are associated with helminth immune evasion and aggravation of tissue damages. This review summarizes the progress of researches on type 1/2 immune responses-associated signaling pathways mediated by helminth infections in hosts.
