Progress of researches on developmental processes and reproduction mode of Pneumocystis.
10.16250/j.32.1374.2022289
- Author:
T XUE
1
;
W DU
2
;
J WANG
3
Author Information
1. National Health Commission Key Laboratory of Pneumoconiosis, Key Laboratory of Respiratory Diseases of Shanxi Province, Key Laboratory of Prevention, Treatment and Fundamental Studies for Respiratory Diseases of Shanxi Province, Department of Respiratory and Critical Care Medicine, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
2. Department of Clinical Laboratory, the People's Hospital of Lüliang, Shanxi Province, China.
3. Department of Nosocomial Infection Management, The First Hospital of Shanxi Medical University, Shanxi Province, China.
- Publication Type:Journal Article
- Keywords:
Asexual reproduction;
Development;
Reproduction mode;
Sexual reproduction
- MeSH:
Humans;
Lung/microbiology*;
Pneumocystis/genetics*;
Pneumonia, Pneumocystis/microbiology*
- From:
Chinese Journal of Schistosomiasis Control
2023;35(5):522-528
- CountryChina
- Language:Chinese
-
Abstract:
Pneumocystis, an important opportunistic fungal pathogen that parasitizes in multiple mammalian lungs, may cause life-threatening Pneumocystis pneumonia (PCP) and even death among immunocompromised individuals. With the rapid development of high-throughput sequencing and multi-omics technologies, systematic comparative analyses of genome, transcriptome, and whole-genome sequencing results demonstrate that Pneumocystis is a type of obligate biotrophic fungi, and requires obtaining nutrition from hosts. In addition, sexual reproduction is an essential process for Pneumocystis survival, production and transmission, and asexual reproduction facilitates Pneumocystis survival, which provides new insights into understanding of the whole developmental process of Pneumocystis in the host lung and inter-host transmission of Pneumocystis. This review summarizes the advances in the reproduction mode of Pneumocystis and underlying mechanisms, which provides insights into prevention and treatment of PCP, notably for the prophylaxis against nosocomial transmission of PCP.
