Recent advances in mass spectrometry imaging and its application in drug research
10.11665/j.issn.1000-5048.2023091901
- VernacularTitle:质谱成像技术前沿进展及其在药物研究中的应用
- Author:
Songkai WANG
1
;
Yuchen ZOU
;
Shipeng SUN
;
Zhiye YAN
;
Weiwei TANG
;
Ping LI
;
Bin LI
Author Information
1. 中国药科大学多靶标天然药物全国重点实验室
- Publication Type:Journal Article
- Keywords:
mass spectrometry imaging;
tissue distribution;
preclinical drug research;
drug delivery;
pharmaceutical analysis;
analysis of Chinese medicine
- From:
Journal of China Pharmaceutical University
2023;54(6):653-661
- CountryChina
- Language:Chinese
-
Abstract:
Mass spectrometry imaging (MSI), a label-free molecular imaging technique, has been applied widely in the spatial localization of small molecule metabolites, lipids, peptides, and proteins, with its unique advantage of high spatial resolving power compared to traditional liquid chromatography-mass spectrometry (LC-MS).With the nonstop advancement of its achievable sensitivity and spatial resolution, MSI technique has been providing novel perspectives into the preclinical studies of drugs, such as in vivo localization of drugs and their metabolites, visualization of drug metabolism, and drug delivery tracking.This review introduces the basics of MSI techniques, including basic principles, key features, technical advantages, and limitations, with particular highlight of the recent applications of MSI in drug efficacy and safety evaluation, drug distribution research, drug delivery research, and analysis of Chinese medicine from recent publications, aiming to promote the utilization and further expansion of MSI in the research and development of drugs.
