Progress of research on the pharmacological effects and mechanisms of emodin
10.11665/j.issn.1000-5048.2023052501
- VernacularTitle:大黄素的药理作用机制研究进展
- Author:
Congyu WU
1
;
Yue ZHOU
;
Luxi SHANGGUAN
;
Yani YANG
;
Jingya WANG
;
Junhe YU
;
Shuaishuai GONG
;
Junping KOU
Author Information
1. 中国药科大学中药学院中药药理与中医药学系
- Publication Type:Journal Article
- Keywords:
emodin;
pharmacological activity;
mechanism;
signaling pathway;
clinical application
- From:
Journal of China Pharmaceutical University
2023;54(5):634-643
- CountryChina
- Language:Chinese
-
Abstract:
As an active hydroxyanthraquinone ingredient, emodin is abundant in Chinese medicine herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum.Modern pharmacological studies have shown that emodin has a variety of pharmacological activities including anti-tumor, anti-inflammatory and immunoregulatory, antibacterial and anti-viral effects, myocardial protection, neuroprotection, renal protection, bone protection, antifibrosis and so on, which indicate its high medicinal value and broad application prospects.This article aims to summarize the progress in the pharmacological activity and mechanism of action of emodin published in domestic and international journals over the last 5 years and highlight the potential targets and molecular signaling pathways linked with emodin, so as to provide some clues and references for further development and clinical application of emodin.
