Synthesis and antifungal evaluation of chalcone derivatives combined with fluconazole against drug-resistant Candida albicans
10.11665/j.issn.1000-5048.2023041002
- VernacularTitle:查耳酮衍生物的合成及联合氟康唑抗耐药白色念珠菌活性
- Author:
Yunhong SHEN
;
Hongjie CHEN
;
Zewei MAO
;
Zhengxiao HUANG
;
Chunyan HU
- Publication Type:Journal Article
- Keywords:
chalcone derivatives;
synthesis;
antifungal activity;
drug-resistant Candida albicans
- From:
Journal of China Pharmaceutical University
2023;54(5):564-568
- CountryChina
- Language:Chinese
-
Abstract:
Chalcone is a common scaffold in natural products with optimal properties and biological activities.In this study, we designed and prepared eight new coumarin-chalcone derivatives (5a-5h), and confirmed their structures by 1H NMR and 13C NMR. Their in vitro antifungal activity combined with fluconazole (FLC) against drug-resistant Candida albicans was tested by microdilution method.The results indicated that most chalcone derivatives showed good antifungal activity against drug resistant Candida albicans with FLC, particularly with compound 5g displaying better antifungal activity (MIC50 = 5.60 μg/mL) than FLC (MIC50 = 200 μg/mL) when combined with FLC, so, these derivatives could be used as synergists of antifungal drugs.
