Research progress of palmitoylation in non-alcoholic fatty liver disease and related liver diseases
10.11665/j.issn.1000-5048.2023040602
- VernacularTitle:蛋白棕榈酰化修饰在非酒精性脂肪性肝病相关疾病中作用机制的研究进展
- Author:
Yalin ZHANG
1
;
Li YAN
;
Fengyu JU
;
Wenhui WANG
;
Ye YU
Author Information
1. 中国药科大学基础医学与临床药学学院
- Publication Type:Journal Article
- Keywords:
non-alcoholic fatty liver disease;
non-alcoholic fatty liver;
non-alcoholic steatohepatitis;
palmitoylation;
palmitoyltransferase
- From:
Journal of China Pharmaceutical University
2023;54(5):536-543
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) has become a major public health hazard threatening human health worldwide.Yet, due to its complex pathogenesis, new drug development is difficult, with still insufficient clinical medication.Palmitoylation is a universal posttranslational modification of proteins catalyzed by palmitoyltransferase, affecting their stability, membrane localization and function.Recent studies have shown that palmitoylation is closely associated with NAFLD.This review summarizes the mechanisms of palmitoylation in NAFLD and analyzes the expression levels of the palmitoyltransferase family in liver tissues of NAFLD patients from GEO database, aiming to provide important clues to explore new mechanisms for NAFLD.
