Research progress on morphology of macular foveal avascular zone in ocular diseases based on optical coherence tomography angiography measurement
10.3980/j.issn.1672-5123.2024.1.09
- VernacularTitle:基于OCTA测量黄斑中心凹无血管区形态在眼部疾病中的应用研究进展
- Author:
Jinyuan SUI
1
,
2
,
3
,
4
;
Haoru LI
1
,
2
,
3
,
4
;
Yang BAI
1
,
2
,
3
,
4
;
Bei DU
1
,
2
,
3
,
4
;
Ruihua WEI
1
,
2
,
3
,
4
Author Information
1. Tianjin Medical University Eye Hospital
2. School of Optometry and Eye Institute
3. Tianjin Branch of National Clinical Research Center for Ocular Disease
4. Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin 300384, China
- Publication Type:Journal Article
- Keywords:
foveal avascular zone;
optical coherence tomography angiography(OCTA);
circularity index;
high myopia;
diabetic retinopathy
- From:
International Eye Science
2024;24(1):48-52
- CountryChina
- Language:Chinese
-
Abstract:
The foveal avascular zone(FAZ)is the most sensitive region of the retina, which is interconnected by the macular capillary plexus. Its morphology can indirectly reflect the alterations of macular microcirculation. With strong repeatability and reliability, optical coherence tomography angiography(OCTA)can non-invasively visualize and quantify the FAZ. The great value of OCTA makes it an important supplemental examination tool in ophthalmology and other professions. The area and perimeter of FAZ have been demonstrated to be an effective clinical diagnostic indicator in high myopia, diabetic retinopathy, glaucoma and other ocular diseases. In recent years, the geometry of FAZ has also proven to have clinical value. The parameters describing the geometry of FAZ, such as circularity index, acircularity index and axial ratio, provide a new perspective for ocular disease research. The comprehensive investigation of the morphological characteristics of the FAZ is helpful to explore the pathological mechanism of the occurrence and development of ocular diseases, predict preclinical changes, make pathological stages of the disease precise, and provide a theoretical basis for monitoring the disease's progression and assessing patients' visual prognosis.
