Establishment and evaluation of the polygenic disease risk prediction model
10.19428/j.cnki.sjpm.2023.22876
- VernacularTitle:多基因疾病风险模型的建立与评估
- Author:
Xiaoqiong ZHU
1
;
Xiong ZHOU
2
;
Peng CAI
2
;
Yida HE
2
;
Hongwei ZHANG
2
;
Xiaojie TAN
2
;
Guangwen CAO
2
Author Information
1. Department of Nutrition and Food Hygiene， School of Public Health， Anhui Medical University， Hefei， Anhui 230032， China
2. Department of Epidemiology， Faculty of Naval Medicine， Naval Medical University， Shanghai Key Laboratory of Medical Bio Protection and Key Laboratory of Biological Defense， Shanghai 200433， China
- Publication Type:Journal Article
- Keywords:
polygenic risk score;
risk prediction model;
single-nucleotide polymorphism;
environmental factor
- From:
Shanghai Journal of Preventive Medicine
2023;35(10):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
To establish a disease risk prediction model based on genetic susceptibility genes and environmental risk factors， which can target high-risk population as early as possible， and intervene in the environmental risk factors in this population. Moreover， accurate screening of genetically susceptible populations can enhance the efficiency of health system. In recent years， with the maturation and cost reduction of high-throughput gene testing， gene testing has been widely used in individual clinical decision-making and will play a more important role in medical and health decision-making. The correlation between genetic testing and disease risk prediction is increasing， making it a prominent research topic in this field. This review summarizes the approaches for establishing and evaluating risk prediction models and discusses potential future challenges and opportunities.
