Research progress on immunomodulatory properties of periodontal ligament stem cells
10.12016/j.issn.2096-1456.2024.01.012
- Author:
WEN Wen
1
,
2
,
3
,
4
;
TIAN Yuyang
1
,
2
,
3
,
4
;
XIE Xudong
1
,
2
,
3
,
4
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Center for Stomatology &
3. National Clinical Research Center for Oral Diseases &
4. Department of Periodontics, West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
periodontal ligament stem cells / tissue regeneration / immunomodulatory properties / acquired immunity / innate immunity / neutrophile granulocyte / mesenchymal stem cells / inflammation
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(1):76-80
- CountryChina
- Language:Chinese
-
Abstract:
Periodontal ligament stem cells (PDLSCs) have the potential for multidirectional differentiation and are the preferred seed cells for periodontal tissue regeneration. In recent years, a large number of studies have confirmed that PDLSCs also possess broad immunomodulatory properties. Therefore, in-depth exploration of their specific molecular mechanisms is of great significance for the treatment of periodontitis. The aim of this paper is to summarize the research progress on the regulation of PDLSCs on various immune cells and the effect of the inflammatory environment on the immune characteristics of PDLSCs to provide an important theoretical basis for the allotransplantation of PDLSCs and improve the therapeutic effect of periodontal tissue regeneration. Studies have shown that PDLSCs possess a certain degree of immunosuppressive effect on both innate and acquired immune cells, and inflammatory stimulation may lead to the impairment of the immunoregulatory properties of PDLSCs. However, current studies are mainly limited to in vitro cell tests and lack in-depth studies on the immunomodulatory effects of PDLSCs in vivo. In vivo studies based on cell lineage tracing and conditional gene knockout technology may become the main directions for future research.
- Full text:牙周膜干细胞免疫调节特性的研究进展.pdf
