Treatment of Inflammatory Bowel Disease by Targeting M1/M2 Macrophage Polarization Balance with Traditional Chinese Medicine and Active Components： A Review
10.13422/j.cnki.syfjx.20231941
- VernacularTitle:中药及有效成分靶向M1/M2巨噬细胞极化平衡治疗炎症性肠病的研究进展
- Author:
Yi LIU
1
;
Yuan LIU
2
;
Zhiqi SUN
1
;
Mingyuan LU
1
Author Information
1. Shandong University of Traditional Chinese Medicine（TCM）， Jinan 250300， China
2. The First Clinical Medical School of Shandong University of TCM，Jinan 250300， China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
active components;
macrophage polarization;
inflammatory bowel disease;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(2):276-286
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease （IBD）， consisting of ulcerative colitis and Crohn's disease， is a chronic relapsing inflammatory gastrointestinal disease closely associated with immune dysfunction. The pathogenesis of IBD is closely related to genetic susceptibility， immune system dysfunction， environmental change， and intestinal microbial dysbiosis. Modern research has found that macrophage polarization plays an important role in the development of IBD and can affect the level of inflammatory response， intestinal mucosal repair， and intestinal microbial balance， making it a potential target for IBD treatment. Increasing evidence suggests that traditional Chinese medicine and its active components can regulate macrophage polarization through multiple pathways and balance the M1/M2 macrophage ratio， thus inhibiting inflammatory response， promoting intestinal mucosal repair， and slowing down the progression of IBD. This article summarized the biological processes and targets involved in macrophage polarization and discussed its impact on IBD. It also provided a brief overview of the latest research on how traditional Chinese medicine and its active components can improve IBD by regulating macrophage polarization， so as to provide new directions and strategies for the clinical application of traditional Chinese medicine in IBD treatment.
