Transporter-mediated Nano-delivery System in Promoting Oral Absorption of Drugs：A Review
10.13422/j.cnki.syfjx.20230863
- VernacularTitle:转运体介导的纳米递送系统促进药物口服吸收的研究进展
- Author:
Na TIAN
1
;
Yanqing ZHANG
1
;
Wei LI
1
;
Leilei FANG
1
;
Junbo XIE
2
Author Information
1. School of Biotechnology and Food Science，Tianjin University of Commerce，Tianjin 300134，China
2. School of Chinese Materia Medica，Tianjin University of Traditional Chinese Medicine， Tianjin 301617，China
- Publication Type:Journal Article
- Keywords:
nano-delivery system;
intestinal tract;
transporter-mediated;
drugs;
oral bioavailability;
modification strategy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(2):254-266
- CountryChina
- Language:Chinese
-
Abstract:
Oral administration is the most convenient way of drug delivery， but due to the existence of intestinal barrier， the oral bioavailability of drugs is generally low， especially for drugs with low water solubility， poor permeability and macromolecules. For decades， researchers have demonstrated that nano-delivery system is one of the most effective strategies to solve this problem， but nano-delivery systems have shown limited improvement in the oral bioavailability of drugs. Therefore， researchers have proposed to use transporter-mediated nano-delivery systems to promote the oral absorption of drugs. The intestinal tract were highly expressed as a transporter for ingesting various nutrients（such as glucose， oligopeptides and bile acids）， which was an excellent target of oral drug delivery system. Its substrate were modified on the nano-delivery system， and the loaded drugs could cross the intestinal barrier and enter the systemic circulation more efficiently through the targeting effect of transporters. At present， more and more evidences supported the potential of transporters in the field of oral drug delivery system. Therefore， this paper reviewed the research on intestinal transporters-mediated nano-delivery system to promote oral absorption of drugs， including the distribution of intestinal transporters， three strategies of transporter substrate modification， the transport properties of different types of transporters and their effects of mediating the nano-delivery system for promoting the oral absorption of drugs or treating diseases， with the aim of providing an important theoretical reference for the development of intestinal targeted nano-delivery systems.
