Chinese Medicine Intervention in Signaling Pathways Related to Diabetic Ulcer： A Review
10.13422/j.cnki.syfjx.20230424
- VernacularTitle:中药干预糖尿病溃疡相关信号通路研究进展
- Author:
Xiaotao WEI
1
;
Zhijun HE
2
;
Tao LIU
2
;
Jinfeng WEI
3
;
Jinpeng LI
2
;
Yuan SONG
2
;
Jie CHEN
2
;
Haigang WANG
4
;
Yuanxu HE
5
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730000， China
3. Jiugang Hospital， Jiayuguan 735100， China
4. Second Provincial People's Hospital of Gansu， Lanzhou 730000， China
5. The Fourth Affiliated Hospital of Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
diabetes;
ulcer;
wound healing;
signaling pathway;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(2):212-220
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic ulcer （DU） wound is one of the chronic and serious complications of diabetes characterized by prolonged wound healing， and it is more common in foot and lower extremity ulcers. DU has brought great economic and psychological pressure to patients and seriously affected the quality of life of patients because of its great difficulty in treatment， long treatment process， and high morbidity and mortality. Therefore， how to help the rapid healing of DU wounds， reduce the disability rate and mortality rate， protect limb function， and improve the quality of life is an important topic and hot spot in the field of medical research. The pathogenesis of DU is complex， mainly including microcirculation disorder， peripheral neuropathy， inflammation and infection， and excessive apoptosis of cells， involving physiological processes such as wound inflammation， granulation tissue hyperplasia and re-epithelialization. A large number of previous studies have found that Chinese medicine can regulate phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， Wnt/β-catenin， nuclear factor-κB （NF-κB）， Notch， nuclear factor E2-related factor 2 （Nrf2）， transforming growth factor-β （TGF-β）/Smad， and other signaling pathways， regulate abnormal glucose metabolism， improve microcirculation， inhibit inflammation and oxidative stress， regulate cell proliferation and excessive apoptosis， and promote wound tissue growth to promote the rapid healing of DU wounds under the guidance of treatment based on traditional Chinese medicine （TCM） syndrome differentiation and internal and external treatment. Therefore， this paper reviewed Chinese medicinal monomers or Chinese medicinal compounds in recent years in regulating the above signaling pathways and the expression of key protein molecules and promoting the rapid healing of DU wounds， aiming to provide ideas and a theoretical basis for the in-depth study and clinical application of Chinese medicine in promoting the healing of DU wounds.
