Acute Tubular Necrosis in a Kidney Transplant Patient Using Benzbromarone: A Case Report.
- Author:
Seung Seok HAN
1
;
Sun Moon KIM
;
Seol Bong YOO
;
Jongwon HA
;
Yon Su KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. yonsukim@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Benzbromarone;
Kidney recipient;
Acute tubular necrosis
- MeSH:
Azotemia;
Benzbromarone;
Biopsy;
Gout;
Humans;
Hypersensitivity;
Hyperuricemia;
Kidney;
Kidney Calculi;
Korea;
Male;
Necrosis;
Transplants;
Uric Acid;
Young Adult
- From:The Journal of the Korean Society for Transplantation
2008;22(2):274-277
- CountryRepublic of Korea
- Language:English
-
Abstract:
Benzbromarone is a uricosuric agent for hyperuricemia and gout. Some of its well-known side effects include hypersensitivity, renal calculi, and gastrointestinal problems. Although the drug was withdrawn from U.S. market due to severe hepatotoxicity, it is still available in some countries including Korea. We describe a 19-year-old male who was admitted with general weakness and azotemia after use of benzbromarone. A kidney biopsy revealed acute tubular necrosis without an evidence of urate nephropathy. After discontinuation of benzbromarone, the renal function returned to baseline. This is the first case of acute tubular necrosis associated with benzbromarone use.
