Evaluation of cholestatic liver disease animal model based on clinical syndrome characteristics of integrated traditional Chinese and Western medicine
10.3969/j.issn.1001-5256.2023.12.031
- VernacularTitle:基于中西医临床病证特点的胆汁淤积性肝病动物模型评价
- Author:
Zhengwang ZHU
1
;
Pingsheng ZHU
1
;
Mingsan MIAO
2
Author Information
1. The First Clinical Medical College, Henan University of Chinese Medicine， Zhengzhou 450046， China
2. School of Pharmacy， Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Review
- Keywords:
Cholestasis;
Models， Animal;
Integrated Traditional Chinese Medicine & Western Medicine
- From:
Journal of Clinical Hepatology
2023;39(12):2959-2964
- CountryChina
- Language:Chinese
-
Abstract:
Cholestatic liver disease is a common disease of the hepatobiliary system. Its etiology and pathogenesis are complex. The establishment of an appropriate animal model of cholestatic liver disease is the basis for further study of its pathogenesis and prevention. This study summarized the existing modeling methods， mechanisms， and characteristics of this model， and analyzed its alignment with the clinical disease and syndrome characteristics of integrated traditional Chinese and Western medicine based on the modern clinical diagnostic criteria and traditional Chinese medicine syndrome characteristics of cholestatic liver disease， so as to provide a reference for establishing standard animal models and evaluation methods for cholestatic liver disease that accord better with the clinical practice of integrated traditional Chinese and Western medicine.
