Regulatory role of mechanical forces in the formation of liver organoids
10.3969/j.issn.1001-5256.2023.12.030
- VernacularTitle:机械力在肝脏类器官形成中的调控作用
- Author:
Ning WANG
1
;
Wenliang LYU
1
Author Information
1. Department of Infectious Diseases， Guang’anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China
- Publication Type:Review
- Keywords:
Organoids;
Liver;
Biological Factors;
Cellular Microenvironment
- From:
Journal of Clinical Hepatology
2023;39(12):2952-2958
- CountryChina
- Language:Chinese
-
Abstract:
In recent years， the continuous advances in material sciences and techniques have helped with the establishment and development of liver organoids that can simulate the structure and function of organs in vivo. In addition to the research on traditional biological factors， the construction of microenvironments with different mechanical cues to investigate the influence of mechanical stimulation on the growth of liver organoids has also become a research focus. This article first discusses the development of liver organoids and then reviews the influence of mechanical forces of different properties on the formation of liver organoids， so as to lay a foundation for the construction of more complex and ordered liver organoids in vitro and provide ideal research models for understanding the interaction between biological and mechanical factors in the formation of liver organoids.
