Research advances in mesenchymal stem cells and their exosomes in treatment of autoimmune hepatitis
10.3969/j.issn.1001-5256.2023.12.025
- VernacularTitle:间充质干细胞及其外泌体治疗自身免疫性肝炎的研究进展
- Author:
Longlong LUO
1
;
Lifei WANG
1
;
Ying ZHENG
2
;
Bin LI
2
;
Lixia LU
2
;
Chuyi LI
2
;
Xiaohui YU
2
;
Jiucong ZHANG
2
Author Information
1. The First Clinical Medical School， Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Department of Gastroenterology， The 940 Hospital of Joint Logistic Support Force of PLA， Lanzhou 730050， China
- Publication Type:Review
- Keywords:
Hepatitis， Autoimmune;
Mesenchymal Stem Cells;
Exosomes;
Therapeutics
- From:
Journal of Clinical Hepatology
2023;39(12):2920-2925
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune hepatitis （AIH） is a type of chronic hepatitis caused by the autoimmune system attacking hepatocytes， and its chronic progression may lead to liver cirrhosis and even hepatocellular carcinoma. Currently， pharmacotherapy and liver transplantation are the main treatment methods for AIH， but both methods have their own limitations， which limits the clinical benefits of patients. Therefore， it is a critical issue to search for new therapeutic agents and methods. Recent studies have shown that mesenchymal stem cells （MSC） and their exosomes can improve the symptoms of patients with AIH by suppressing inflammatory response， enhancing the regeneration of hepatocytes， and regulating the immune system and thus have wide application prospects in the treatment of AIH. By summarizing related articles， this article reviews the possible mechanisms and application of MSC and their exosomes in the treatment of AIH， in order to provide new ideas for the clinical treatment of AIH.
