Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy
10.1007/s13770-022-00503-y
- Author:
Yuntong SUN
1
;
Fengtian SUN
;
Wenrong XU
;
Hui QIAN
Author Information
1. Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, China
- Publication Type:REVIEW ARTICLE
- From:
Tissue Engineering and Regenerative Medicine
2023;20(2):157-175
- CountryRepublic of Korea
- Language:English
-
Abstract:
Extracellular vesicles (EVs)-based cell-free strategy has shown therapeutic potential in tissue regeneration. Due to their important roles in intercellular communications and their natural ability to shield cargos from degradation, EVs are also emerged as novel delivery vehicles for various bioactive molecules and drugs. Accumulating studies have revealed that EVs can be modified to enhance their efficacy and specificity for the treatment of many diseases. Engineered EVs are poised as the next generation of targeted delivery platform in the field of precision therapy. In this review, the unique properties of EVs are overviewed in terms of their biogenesis, contents, surface features and biological functions, and the recent advances in the strategies of engineered EVs construction are summarized. Additionally, we also discuss the potential applications of engineered EVs in targeted therapy of cancer and damaged tissues, and evaluate the opportunities and challenges for translating them into clinical practice.
