Expression of the Tissue Inhibitor of Matrix-Metalloproteinase (TIMP-2) in Cervical Carcinoma.
- Author:
Do Young KIM
1
;
Kwang Sun SUH
;
Heung Tae NOH
;
Yun Ee RHEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Chungnam National University, Taejeon, Korea.
- Publication Type:Original Article
- Keywords:
Cervical cancer;
Tissue inhibitor of matrix-metalloproteinase (TIMP-2)
- MeSH:
Carcinoma, Squamous Cell;
Hand;
Lymph Nodes;
Neoplasm Metastasis;
Recurrence;
Stromal Cells;
Tissue Inhibitor of Metalloproteinase-2;
Uterine Cervical Neoplasms
- From:Korean Journal of Obstetrics and Gynecology
2004;47(6):1165-1170
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The present study was conducted to evaluate the tissue inhibitor of matrix-metalloproteinase (TIMP-2), which leads to tumor proliferation, invasion and metastasis and which can be used as a prognostic factor for cervical carcinoma, and to correlate TIMP-2 with recurrence in cervical carcinoma. METHODS: Thirty-three cases of cervical carcinoma and ten control cervices were analysed for expression of TIMP-2 by immunohistochemical staining. Results were analysed for possible correlation with prognostic factors. RESULTS: Lymph node metastasis, lymphovascular invasion, and recurrence groups showed a lower expression tendency of TIMP-2 in tumor cells (0.67 vs 0.88, 0.77 vs 0.93, 0.78 vs 0.91) (p>0.05). However, there was no statistical significance in the correlation of TIMP-2 expression with tumor variables. On the other hand, in stromal cells, deep invasion (>or=5 mm), squamous cell carcinoma groups showed a higher expression tendency of TIMP-2 (0.80 vs 0.67, 0.74 vs 0.40) (p>0.05) but, there was no statistical significance. However, recurrence group showed a significantly lower expression of TIMP-2 in stromal cells (0.33 vs 0.83) (p<0.05). CONCLUSION: In spite of no statistically significant correlation in tumor cells, recurrence group showed a significantly lower expression of TIMP-2 in stromal cells. Therefor there was an inverse correlation between expression of TIMP-2 in stromal cell and recurrence. These results indicate that expression of TIMP-2 in stromal cells is closely correlated with the recurrence of cervical carcinoma.
