Expression of Angiopoietin-1 and Angiopoietin-2 mRNA in Eutopic and Ectopic Endometrium.
- Author:
Ji Young LEE
1
;
Seong Soo AN
;
Byung Il YUN
;
Sung Eun HUR
;
In Sook SOHN
;
Soo Nyung KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Endometriosis;
Angiopoietin-1;
Angiopoietin-2
- MeSH:
Angiopoietin-1*;
Angiopoietin-2*;
DNA, Complementary;
Endometriosis;
Endometrium*;
Female;
Follicular Phase;
Humans;
Menstrual Cycle;
Polymerase Chain Reaction;
RNA;
RNA, Messenger*
- From:Korean Journal of Obstetrics and Gynecology
2004;47(6):1171-1178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the mRNA expression of Angiopoietin (Ang)-1 and Ang-2 in ectopic and eutopic endometrium from women with or without endometriosis throughout the menstrual cycle. METHODS: Total RNA was extracted and reverse transcribed into cDNA. The expression of Ang-1 and Ang-2 was examined by quantative competitive PCR (QC PCR) and each result was analyzed by Kruskal- Wallis analysis and Mann-Whitney U-test. RESULTS: The expression of Ang-1 mRNA was statistically significantly higher in endometrium of follicular phase from women with endometriosis compared to that from normal ones in the follicular phase. Endometriotic tissues expressed significantly lower Ang-2 mRNA compared to endometrium from women without endometriosis. CONCLUSION: We suggested that the expression of Ang-1 mRNA could be associated with the pathogenesis of endometriosis and might have a role as neovascularizaton and survival of ectopic endometrium.
