Evaluation of Marsh's Pharmacokinetic Parameter Set for Target Controlled Infusion of Propofol in Korean.
10.4097/kjae.2001.40.3.282
- Author:
Soon Young JEON
1
;
Ho Yeong KIL
;
Kwang Min KIM
Author Information
1. Department of Anesthesiology, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Anesthetics, intravenous: propofol;
Pharmacokinetics: pharmacokinetic parameter;
Statistics: performance error
- MeSH:
Adult;
Anesthesia;
Atropine;
Cardiac Output;
Chromatography, High Pressure Liquid;
Humans;
Orthopedics;
Premedication;
Propofol*;
Radial Artery;
Recovery Room;
Veins
- From:Korean Journal of Anesthesiology
2001;40(3):282-292
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Marsh's pharmacokinetic parameter set is the most widely used parameter for target controlled infusion for propofol. However, Marsh's model was derived from a European population, and it is uncertain whether this model is accurate for Koreans. METHODS: Thirty ASA 1 or 2 adult patients undergoing orthopedic surgery participated in this study. Atropine 0.5 mg was injected for premedication. Anesthesia was induced by a TCI of propofol with a target concentration of 6 microgram/ml and maintained around 3 - 5 microgram/ml according to the bispectral index (35 - 45). In the middle of surgery, target concentrations were increased to 6 microgram/ml and maintained until effect site concentration was the same concentration. Three minutes after equilibration, 3 ml of blood was drawn from the radial artery and contralateral antecubital cephalic vein for measuring blood concentration using HPLC. Target concentrations were gradually decreased at the interval of 1 microgram/ml until the end of surgery and a blood sample was drawn as described in the method. A sample for every 1 microgram/ml was collected in the recovery room. Performance error of the predicted concentration of blood was calculated. RESULTS: The performance error was -12.86 - 16.55% for 1 - 6 microgram/ml of predicted concentration. Measured concentrations were higher than predicted at higher concentrations, but lower at lower concentrations. Measured cardiac output and arteriovenous concentration differences at 1 - 6 microgram/ml showed no difference. CONCLUSIONS: Marsh's pharmacokinetic model was accurate for propofol TCI in Koreans in terms of relatively low performance error (< 20%) in the concentration range of 1 - 6 microgram/ml.
